The incidence and distribution of CpG----TpG transitions in the coagulation factor IX gene. A fresh look at CpG mutational hotspots.

Abstract

The mutations of 76 haemophilia B patients representing the whole population registered with the Malmö haemophilia centre (42) and referrals from the UK, were characterised. RFLP haplotype analysis of the defective genes indicated that 51 single base pair substitutions were definitely of independent origin and 27 of these were CpG----TpG or CpA transitions… (More)

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Cite this paper

@article{Green1990TheIA, title={The incidence and distribution of CpG----TpG transitions in the coagulation factor IX gene. A fresh look at CpG mutational hotspots.}, author={P. M. Green and Andr{\'e} Montandon and D. R. Bentley and R. Ljung and Ingmarie Nilsson and F. Giannelli}, journal={Nucleic acids research}, year={1990}, volume={18 11}, pages={3227-31} }