The inactivation of monomolecular films of protein and its relation to the lifetime of active radicals formed in water by x-radiation.

@article{Smith1954TheIO,
  title={The inactivation of monomolecular films of protein and its relation to the lifetime of active radicals formed in water by x-radiation.},
  author={Carole L. Smith},
  journal={Archives of biochemistry and biophysics},
  year={1954},
  volume={50 2},
  pages={
          322-36
        }
}
  • C. Smith
  • Published 1 June 1954
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
Abstract The inactivation by x-rays of monomolecular layers of catalase and of bovine serum albumin (BSA) in pure air-free water has been studied. No measurable inactivation can be detected with doses of less than about 100,000 r. With doses of 500,000 r. the respective inactiyations are 48 and 12%. The ionic yields for catalase and BSA in solution have also been measured and the values obtained are 0.044 and 0.023 molecules/ion pair, respectively. From these measurements, the half-life time of… Expand
13 Citations
Inactivation of deoxyribonuclease by x-rays. II. The kinetics of inactivation in aqueous solution.
  • S. Okada
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1957
TLDR
The kinetics suggest that only one in 9.3 free radicals which react with one enzyme molecule is effective in causing loss of enzymatic activity, which is of the first order rather than the second order. Expand
Monolayer technique to study effects of lonizing radiations on histone.
TLDR
It was concluded that irradiation produces a degree of fragmentation and some modifications in the histone molecules, which cause hycrophlilic groups to go into the aqueous under phase and results in lowering of the residual charges carried by the molecules in the monolayer. Expand
Irradiation effects on enzymes (in vitro)
Enzymes are the essential catalysts of the breakdown and synthesis of vital constituents in cells of living organisms and usually display a high degree of specificity. Without enzymes the cells couldExpand
Das aktive Wasser
Bei der Einwirkung der energiereichen Strahlen auf flussiges Wasser entstehen Wasserradikale, und zwar vor allem H und OH, in Gegenwart von O2 das Radikal HO2. In saurer Losung geht das Radikal H inExpand
Die Wirkung von Licht und Strahlung auf die Zelle
In dem vorliegenden Abschnitt sollen die Grundlagen der Wirkungen von Licht und Strahlung auf biologische Objekte, besonders auf die einzelne Zelle, dargestellt werden. Hieruber gibt es eine hochstExpand
Biologische Grundlagen der Röntgentherapie
Schon bald nach der Entdeckung der Rontgen- und Radiumstrahlen wurde ihre biologische Wirksamkeit, zuerst in der Form von Strahlenreaktionen der Haut, beobachtet. Diese Feststellung bildete denExpand
Dosiswirkungsbeziehung und Mikroverteilung der absorbierten Energie
Es soll nun die Frage nach der Ausdehnung der empfindlichen Bereiche gestellt werden. In Teil II wurde gezeigt, das jeder Dosiswirkungsbeziehung eine Mindestzahl S der im Mittel fur den TesteffektExpand
Treffertheorie und alternative Deutung der Dosiswirkungsbeziehungen
Στoχℴς bedeutet ursprunglich Ziel oder Treffbereich. Da das griechische Wort aber auch soviel wie Mutmasung heist, pflegt man die Lehre von den zufalligen Ereignissen als Stochastik zu bezeichnen.Expand
...
1
2
...

References

SHOWING 1-8 OF 8 REFERENCES
The inactivation of an enzyme (carboxypeptidase) by X- and α-radiation
The inactivation of aqueous solutions of pure crystalline carboxypeptidase by X-radiation and α-radiation has been studied. It is concluded that in each case the enzyme molecules are inactivated byExpand
Direct and indirect actions of radiation on viruses and enzymes
TLDR
It is found that the inactivation dose is independent of concentration at high concentrations, and at low concentrations also attains a constant, but lower, value. Expand
Studies on the mechanism of action of ionizing radiations. X. Effect of x-rays on some physicochemical properties of proteins
Abstract On x-irradiation of aqueous solutions of serum albumin, serum globulin, and egg albumin, there was an increase in the absorption of ultraviolet light, the increase being more marked aroundExpand
Inactivation of monomolecular layers of bovine serum albumin with deuterons.
  • F. Hutchinson
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1952
TLDR
It is shown that the inactivation of such layers of bovine serum albumin with deuterons is logarithmic, indicating that the majority of the serologically active units are of the same size. Expand
The inactivation of catalase by deuterons and heat.
  • R. Setlow
  • Chemistry, Medicine
  • Archives of biochemistry and biophysics
  • 1951
TLDR
Evidence for the existence of at least two forms of stable catalase has been presented and data are shown to indicate two possible alternative molecular weights (about 250,000 and 130,000) forCatalase. Expand
Inactivation of enzyme-substrate film by small doses of x-rays.