• Biology, Medicine
  • Published in The journal of gene medicine 2003
  • DOI:10.1002/jgm.340

The in vivo use of chloroquine to promote non-viral gene delivery to the liver via the portal vein and bile duct.

@article{Zhang2003TheIV,
  title={The in vivo use of chloroquine to promote non-viral gene delivery to the liver via the portal vein and bile duct.},
  author={Xiaohong Zhang and Greta J. Sawyer and Xuebin Dong and Ying Qiu and Louise Sarsfield Collins and John Fabre},
  journal={The journal of gene medicine},
  year={2003},
  volume={5 3},
  pages={
          209-18
        }
}
BACKGROUND Assistance with exit from endocytic vesicles is a key factor for non-viral gene delivery, and is a particular challenge in vivo. We have evaluated the in vivo use of chloroquine administered systemically, orally and/or locally for gene delivery to the liver. METHODS The DNA vector (polylysine-molossin) is a 31 amino acid bifunctional synthetic peptide, incorporating an amino terminal chain of 16 lysines for electrostatic binding of DNA. Gene delivery was to the right lateral lobes… CONTINUE READING

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