The in vivo unidirectional conversion of nitro-D-arginine to nitro-L-arginine.

@article{Wang1999TheIV,
  title={The in vivo unidirectional conversion of nitro-D-arginine to nitro-L-arginine.},
  author={Qiong Wang and Michael Cwik and Charles J. Wright and F Cunningham and Dale A. Pelligrino},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1999},
  volume={288 1},
  pages={270-3}
}
We recently reported that nitric oxide synthase in the brain can be inhibited not only by nitro-L-arginine (L-NA) but also by its D-enantiomer nitro-D-arginine (D-NA). In the present study, we found that D-NA, when tested in vitro, was 400 times less potent than L-NA. However, when D-NA was injected in vivo, its L-enantiomer, L-NA, was found to rapidly appear in plasma samples (approximately 1 min), rose to a maximum concentration at 30 min (approximately 40% conversion), and remained at this… CONTINUE READING