The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans.

@article{Ball2006TheIV,
  title={The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans.},
  author={Ronald O. Ball and Glenda Courtney-Martin and Paul B. Pencharz},
  journal={The Journal of nutrition},
  year={2006},
  volume={136 6 Suppl},
  pages={
          1682S-1693S
        }
}
Sulfur amino acid metabolism has been receiving increased attention because of the link to chronic diseases such as cardiovascular disease, Alzheimer's disease, and diabetes. In addition, the role of cysteine and optimal intakes for physiological substrates such as glutathione are currently of considerable interest in human health. Although the dietary indispensability of methionine is not in question, the ability of cysteine to substitute for a portion of its requirement has been the topic of… Expand
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  • Chemistry, Medicine
  • The Journal of nutrition
  • 2020
TLDR
Some broad aspects of human methionine nutrition are touched, including requirements in different life stages, disease, and bioavailability, with some examples from the insights/lessons learned from experiments initially conducted in animals. Expand
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SAA requirements for maintenance of GSH status was deleniated in healthy adult males and in PN-fed human neonates and in healthy men because cysteine is the rate limiting substrate for glutathione (GSH) synthesis. Expand
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Intestinal metabolism of sulfur amino acids
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The present review discusses the evidence of SAA metabolism in the GIT and its functional and nutritional importance in gut function and diseases and indicates that intestinal metabolism of dietary methionine and cysteine is nutritionally important for intestinal mucosal growth. Expand
Sulfur amino acid metabolism and requirements.
TLDR
When SAAs are absent from the diet of healthy adults, methionine is used preferentially for protein synthesis relative to transmethylation, confirming previous findings that methionines is conserved via protein synthesis when SAA availability is low. Expand
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  • R. McPherson, G. Hardy
  • Chemistry, Medicine
  • Current opinion in clinical nutrition and metabolic care
  • 2011
TLDR
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Total Sulfur Amino Acid Requirements Are Not Altered in Children with Chronic Renal Insufficiency, but Minimum Methionine Needs Are Increased.
TLDR
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Impact of medication on protein and amino acid metabolism in the elderly: the sulfur amino acid and paracetamol case
TLDR
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