The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation.

@article{Gupta1995TheIV,
  title={The in vivo pharmacological profile of a 5-HT1 receptor agonist, CP-122,288, a selective inhibitor of neurogenic inflammation.},
  author={Pratibha Gupta and David Brown and P E M Butler and Penny Ellis and Kristine L. Grayson and Gillian Christine Land and John Eugene Macor and Susan Robson and Martin James Wythes and N. B. Shepperson},
  journal={British journal of pharmacology},
  year={1995},
  volume={116 5},
  pages={
          2385-90
        }
}
1. The aim of the present study was to investigate the in vivo pharmacological profile of CP-122,288, an indole-derivative with a conformationally restricted N-methylpyrrolidinyl basic side chain in the C-3 position. This C-3 substituent structurally differentiates CP-122,288 from the 5-HT1D receptor agonist sumatriptan, which possesses an N,N-dimethylaminoethyl group. [Formula: see text] 2. When administered prior to electrical stimulation of the trigeminal ganglion, CP-122,288 (0.3-300 ng kg… CONTINUE READING

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