The in vivo metabolism of tibolone in animal species

  title={The in vivo metabolism of tibolone in animal species},
  author={C. Verhoeven and R. Vos and L. Delbressine},
  journal={European Journal of Drug Metabolism and Pharmacokinetics},
SummaryThein vivo tissue distribution and metabolism of tibolone was studied in different animals to further investigate the compound’s tissue-specificity. Tibolone’s metabolism was studiedin vivo in rats and rabbits by administration of [16-3H]-tibolone and the metabolic pattern was determined in urine and faeces after oral administration to female rats and dogs.The main excretory pathway was found to be excretion in the faeces. Important phase-I metabolic routes were the reduction of the 3… Expand
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