The in vivo mechanism of action of CTLA4Ig.

  title={The in vivo mechanism of action of CTLA4Ig.},
  author={Thomas A. Judge and Aimin Tang and Lisa M. Spain and J Deans-Gratiot and Mohamed H. Sayegh and Lawrence A Turka},
  journal={Journal of immunology},
  volume={156 6},
A single dose of CTLA4Ig, an inhibitor of CD28-mediated T cell costimulation, given 2 days after transplantation induces specific unresponsiveness to alloantigens in vivo. However, the mechanisms responsible are unknown. Using pigeon cytochrome c as a model Ag, we monitored the effect of CTLA4Ig on the fate of Ag-reactive T cells in normal mice and on pigeon cytochrome c-specific TCR transgenic cells adoptively transferred into congenic mice. CTLA4Ig significantly inhibits immunization with… CONTINUE READING
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