The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier.

@article{Niessen2012TheIV,
  title={The in vivo function of mammalian cell and tissue polarity regulators--how to shape and maintain the epidermal barrier.},
  author={Michaela T. Niessen and Sandra Iden and Carien M. Niessen},
  journal={Journal of cell science},
  year={2012},
  volume={125 Pt 15},
  pages={
          3501-10
        }
}
The establishment and maintenance of cell and tissue polarity is crucial for a range of biological processes, such as oriented division, migration, adhesion and barrier function. The molecular pathways that regulate cell and tissue polarity have been extensively studied in lower organisms as well as in mammalian cell culture. By contrast, relatively little is still known about how polarization regulates the in vivo formation and homeostasis of mammalian tissues. Several recent papers have… CONTINUE READING
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References

Publications referenced by this paper.
SHOWING 1-10 OF 90 REFERENCES

Asymmetric cell division: recent developments and their implications for tumour biology

VIEW 4 EXCERPTS
HIGHLY INFLUENTIAL

Robust control of mitotic spindle orientation in the developing epidermis

VIEW 6 EXCERPTS
HIGHLY INFLUENTIAL

Planar cell polarity signaling: from fly development to human disease.

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Adaptation of core mechanisms to generate cell polarity

VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL

Variation in the plane of cell cleavage during the process of stratification in the mouse epidermis

  • I. H. Smart
  • Br. J. Dermatol. 82, 276-282.
  • 1970
VIEW 9 EXCERPTS
HIGHLY INFLUENTIAL

Epidermal wound repair is regulated by the planar cell polarity signaling pathway.

VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL

Planar cell polarity: keeping hairs straight is not so simple.

  • Helen McNeill
  • Biology, Medicine
  • Cold Spring Harbor perspectives in biology
  • 2010
VIEW 7 EXCERPTS
HIGHLY INFLUENTIAL