The in vivo effects of recombinant human interleukin-3: demonstration of basophil differentiation factor, histamine-producing activity, and priming of GM-CSF-responsive progenitors in nonhuman primates.

@article{Mayer1989TheIV,
  title={The in vivo effects of recombinant human interleukin-3: demonstration of basophil differentiation factor, histamine-producing activity, and priming of GM-CSF-responsive progenitors in nonhuman primates.},
  author={Peter Mayer and Peter Valent and Gunther Schmidt and Ekke Liehl and Peter Bettelheim},
  journal={Blood},
  year={1989},
  volume={74 2},
  pages={
          613-21
        }
}
Recently human interleukin-3 (IL-3) produced by molecular cloning was characterized as a growth factor for basophils and eosinophils in human bone marrow cultures. Since we found a similar activity of the human factor on simian bone marrow cells, we investigated the in vivo effects of recombinant human (rh) IL-3 in healthy rhesus monkeys (n = 10). rh IL-3 was administered subcutaneously (SC) to monkeys at different doses (11, 33, and 100 micrograms/kg/d) for 14 days followed by subsequent rh GM… CONTINUE READING

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References

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SHOWING 1-10 OF 36 REFERENCES

Donnen - berg AD , Arai N , Ishizaka K , Ishizaka T : Selective differentiation and proliferation of hematopoietic cells induced by recombinant human interleukins

  • Saito It, K Hatake, AM Dvorak, KM Leiferman
  • Proc Natl Acad Sci USA
  • 1988

Effect of recombinant human granulocyte - macrophage colony - stimulating factor on chemotherapy - induced myelosuppression

  • KS Hutman, Griffin iD, +7 authors LE Schnipper
  • N Engl i Med
  • 1988

Effect ofgranulocyte colony stimulating factor on neutropenia induced by cytotoxic chemothera

  • G Morstyn, LM Souza, +6 authors R Fox
  • Lancet
  • 1988

Human recombinant lL - 3 promotes the growth of human basophils / mast cells

  • B Fagg, K Hirai, K Nakajima, B Stadler
  • Mechanisms of Action and Therapeutic Application…
  • 1988

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