The in vivo dynamics of antigenic variation in Trypanosoma brucei

@article{Mugnier2015TheIV,
  title={The in vivo dynamics of antigenic variation in Trypanosoma brucei},
  author={Monica R. Mugnier and George A. M. Cross and F Nina Papavasiliou},
  journal={Science},
  year={2015},
  volume={347},
  pages={1470-1473}
}
Trypanosoma brucei, a causative agent of African Sleeping Sickness, constantly changes its dense variant surface glycoprotein (VSG) coat to avoid elimination by the immune system of its mammalian host, using an extensive repertoire of dedicated genes. However, the dynamics of VSG expression in T. brucei during an infection are poorly understood. We have developed a method, based on de novo assembly of VSGs, for quantitatively examining the diversity of expressed VSGs in any population of… CONTINUE READING

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