The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.

@article{Zhai2011TheIV,
  title={The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease.},
  author={Jinbin Zhai and Weiguo Zhou and Jian Li and Christopher R Hayworth and Lei Zhang and Hidemi Misawa and Rudiger Klein and Steven S. Scherer and Rita J. Balice-Gordon and Robert Gordon Kalb},
  journal={Human molecular genetics},
  year={2011},
  volume={20 21},
  pages={4116-31}
}
Brain-derived neurotrophic factor (BDNF) and its receptor tropomyosin-related kinase B (TrkB) are widely expressed in the vertebrate nervous system and play a central role in mature neuronal function. In vitro BDNF/TrkB signaling promotes neuronal survival and can help neurons resist toxic insults. Paradoxically, BDNF/TrkB signaling has also been shown, under certain in vitro circumstances, to render neurons vulnerable to insults. We show here that in vivo conditional deletion of TrkB from… CONTINUE READING
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