The in vivo behaviour of a colonic delivery system: a pilot study in man

@article{Steed1994TheIV,
  title={The in vivo behaviour of a colonic delivery system: a pilot study in man},
  author={K. Steed and G. Hooper and P. Ventura and R. Musa and I. Wilding},
  journal={International Journal of Pharmaceutics},
  year={1994},
  volume={112},
  pages={199-206}
}
  • K. Steed, G. Hooper, +2 authors I. Wilding
  • Published 1994
  • Medicine
  • International Journal of Pharmaceutics
  • Abstract Eight healthy male volunteers were recruited for a study to determine the in vivo behaviour of an enteric coated, modified release beclomethasone dipropionate formulation. The non-invasive technique of gamma scintigraphy was used to relate position and integrity of the tablet formulation within the gastrointestinal tract to blood levels of beclomethasone dipropionate and its metabolites. Following fasted administration, tablet integrity was maintained in the stomach, and onset of… CONTINUE READING
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