The in vivo and in vitro metabolic profile of 99mTc-NC100668, a new tracer for imaging venous thromboembolism: identification and biodistribution of the principal radiolabeled metabolite.

@article{Edwards2006TheIV,
  title={The in vivo and in vitro metabolic profile of 99mTc-NC100668, a new tracer for imaging venous thromboembolism: identification and biodistribution of the principal radiolabeled metabolite.},
  author={David Edwards and Mark R Battle and Rochelle Lear and Gill Farrar and David J Barnett and Vanessa Godden and Catherine L Coombes and Alexandra C. M. Oliveira and H{\aa}kan Ahlstr{\"o}m},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 7},
  pages={1128-35}
}
(99m)Tc-NC100668 [Acetyl-Asn-Gln-Glu-Gln-Val-Ser-Pro-Tyr(3-iodo)-Thr-Leu-Leu-Lys-Gly-NC100194] is a radiopharmaceutical imaging agent being developed to aid the diagnosis of thromboembolism. The stability profile of (99m)Tc-NC100668 was investigated by high-performance liquid chromatography (HPLC) after in vitro exposure to blood and plasma obtained from rat and human, as well as to urine and bile obtained from rat. The metabolic profile of (99m)Tc-NC100668 exposed to human and rat hepatic S9… CONTINUE READING
1 Citations
8 References
Similar Papers

References

Publications referenced by this paper.
Showing 1-8 of 8 references

Amino-acid sequence of human alpha 2-antiplasmin

  • HR Lijnen, WE Holmes, B van Hoef, B Wiman, H Rodriguez, D Collen
  • Eur J Biochem
  • 1987
2 Excerpts

Radiochemistry and radiopharmacology, in Nuclear Medicine: Technology and Techniques (Bernier DR, Langan JK, Wells DL eds) pp 162–176

  • KD McElvany, SJ Wagner, MJ Welch
  • Mosby-Year Book Inc, St. Louis
  • 1981
2 Excerpts

Similar Papers

Loading similar papers…