The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.

Abstract

The in vivo Pig-a assay uses flow cytometry to measure phenotypic variants for antibody binding to cell surface glycosylphosphatidylinositol (GPI)-anchored proteins. There is good evidence suggesting that the absence of antibody binding is the result of a mutation in the endogenous X-linked Pig-a gene, which forms the rationale for the assay. Although the… (More)
DOI: 10.1016/j.mrgentox.2014.09.007

Cite this paper

@article{Gollapudi2015TheIV, title={The in vivo Pig-a assay: A report of the International Workshop On Genotoxicity Testing (IWGT) Workgroup.}, author={B Bhaskar Gollapudi and Anthony M. Lynch and Robert H. Heflich and Stephen D. Dertinger and Vasily N. Dobrovolsky and Roland Fr{\"o}tschl and Katsuyoshi Horibata and Michelle O Kenyon and Takafumi Kimoto and David Paul Lovell and Leon F Stankowski and Paul A. White and Kristine L. Witt and Jennifer Y Tanir}, journal={Mutation research. Genetic toxicology and environmental mutagenesis}, year={2015}, volume={783}, pages={23-35} }