The in vitro pharmacological profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity

@article{Smith2008TheIV,
  title={The in vitro pharmacological profile of TD-5108, a selective 5-HT4 receptor agonist with high intrinsic activity},
  author={J. A. M. Smith and David T. Beattie and Daniel G. Marquess and Jeng Pyng Shaw and Ross G. Vickery and Patrick P. A. Humphrey},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={2008},
  volume={378},
  pages={125-137}
}
The in vitro pharmacological profile of TD-5108, a novel, selective 5-HT4 receptor agonist, was compared to that of clinically efficacious gastroprokinetic 5-HT4 receptor agonists. TD-5108 produced an elevation of cyclic adenosine monophosphate in human embryonic kidney 293 cells expressing the human recombinant 5-HT4(c) (h5-HT4(c)) receptor (pEC50 = 8.3) and 5-HT4 receptor-mediated relaxation of the rat esophagus (pEC50 = 7.9) and contraction of the guinea pig colon (pEC50 = 7.9). In all in… 

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