The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway

@article{Rooyen2018TheIV,
  title={The in vitro metabolism of 11β-hydroxyprogesterone and 11-ketoprogesterone to 11-ketodihydrotestosterone in the backdoor pathway},
  author={Desmar{\'e} van Rooyen and R. Gent and Lise Barnard and A. Swart},
  journal={The Journal of Steroid Biochemistry and Molecular Biology},
  year={2018},
  volume={178},
  pages={203-212}
}
  • Desmaré van Rooyen, R. Gent, +1 author A. Swart
  • Published 2018
  • Chemistry, Medicine
  • The Journal of Steroid Biochemistry and Molecular Biology
  • Increased circulating 11β-hydroxyprogesterone (11OHP4), biosynthesised in the human adrenal, is associated with 21-hydroxylase deficiency in congenital adrenal hyperplasia. 17α-hydroxyprogesterone levels are also increased, with the steroid's metabolism to dihydrotestosterone in the backdoor pathway contributing to hyperandrogenic clinical conditions. In this study we investigated the in vitro biosynthesis and downstream metabolism of 11OHP4. Both cytochrome P450 11β-hydroxylase and aldosterone… CONTINUE READING
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