Corpus ID: 27462267

The in vitro formation of glutathione conjugates with the microsomally activated pulmonary bronchiolar aklylating agent and cytotoxin, 4-ipomeanol.

@article{Buckpitt1980TheIV,
  title={The in vitro formation of glutathione conjugates with the microsomally activated pulmonary bronchiolar aklylating agent and cytotoxin, 4-ipomeanol.},
  author={Alan Buckpitt and Michael R. Boyd},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1980},
  volume={215 1},
  pages={
          97-103
        }
}
  • A. Buckpitt, M. Boyd
  • Published 1980
  • Chemistry, Medicine
  • The Journal of pharmacology and experimental therapeutics
Using a new high-pressure anion-exchange chromatographic procedure, two radiolabeled conjugates were separated and assayed quantitatively from incubation mixtures containing lung or liver microsomes, NADPH, [3H]5-ipomeanol and glutathione. The same conjugates were obtained also from similar microsomal preparations containing unlabeled 4-ipomeanol, NADPH and [3H]glutathione. The conjugates were not produced in microsomal incubation mixtures containing only [3H]4-ipomeanol and glutathione, or [3H… Expand
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