The in vitro effects of various lysosomotropic agents on the gut of Schistosoma mansoni schistosomula.

@article{Bogitsh1991TheIV,
  title={The in vitro effects of various lysosomotropic agents on the gut of Schistosoma mansoni schistosomula.},
  author={Burton J. Bogitsh and Geoffrey Davenport},
  journal={The Journal of parasitology},
  year={1991},
  volume={77 2},
  pages={187-93}
}
Cultured Schistosoma mansoni schistosomula of various ages were exposed to several lysosomotropic agents. Weak bases such as chloroquine, ammonium chloride, and acridine orange caused gut swelling upon protonation. The latter compound fluoresced a bright orange indicating the acidic nature of the gut contents. Hydrolysis of ingested L-amino acid methyl esters also resulted in gut swelling, indicating the nonpermeant nature of the resulting L-amino acids. Neither age nor feeding status… CONTINUE READING

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