The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity.

@article{Kaur2009TheIV,
  title={The in vitro effects of selenomethionine on methylmercury-induced neurotoxicity.},
  author={Parvinder Kaur and Lars G Evje and Michael Aschner and Tore Syversen},
  journal={Toxicology in vitro : an international journal published in association with BIBRA},
  year={2009},
  volume={23 3},
  pages={
          378-85
        }
}
Selenium (Se) has been reported to reduce the severity of MeHg-induced neurological deficits. Therefore, we investigated whether 24h. preincubation or 50min. coincubation with selenomethionine (SeMet) was effective in reducing methylmercury (MeHg)-induced cytotoxicity in C6-glioma and B35-neuronal cell lines. As indicators of cytotoxicity, reduced glutathione (GSH), reactive oxygen species (ROS) and mitochondrial activity (MTT) was assessed. Measurement of GSH with the fluorescent indicator MCB… CONTINUE READING
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