The in-vitro and in-vivo inhibitory activity of biflorin in melanoma.

  title={The in-vitro and in-vivo inhibitory activity of biflorin in melanoma.},
  author={Marne Carvalho de Vasconcellos and Daniel Pereira Bezerra and Alu{\'i}sio Marques Fonseca and Ana J{\'e}rsia Ara{\'u}jo and Cl{\'a}udia Pessoa and Telma Leda Gomes de Lemos and Let{\'i}cia V Costa-Lotufo and Manoel Odor{\'i}co de Moraes and Raquel C Montenegro},
  journal={Melanoma research},
  volume={21 2},
Biflorin, an ortho-naphthoquinone, is an active compound found in the roots of Capraria biflora L. It has been reported that biflorin presents anticancer activity, inhibiting both tumor cell line growth in culture and tumor development in mice. The aim of this study was to examine the effectiveness of biflorin treatment using both in-vitro and in-vivo melanoma models. Biflorin displayed considerable cytotoxicity against all tested cell lines, with half maximal inhibitory concentration values… CONTINUE READING