The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2

  title={The in vitro and in vivo anti-tumor effects of MTX-Fe3O4-PLLA-PEG-PLLA microspheres prepared by suspension-enhanced dispersion by supercritical CO2},
  author={Aizheng Chen and Tingting Dang and Shibin Wang and Na Tang and Yuangang Liu and Wenguo Wu},
  journal={Science China Life Sciences},
The in vitro and in vivo anti-tumor efficacy of methotrexate-loaded Fe3O4-poly-L-lactide-poly(ethylene glycol)-poly-L-lactide magnetic composite microspheres (MTX-Fe3O4-PLLA-PEG-PLLA MCMs, MMCMs), which were produced by co-precipitation (C) and microencapsulation (M) in a supercritical process, was evaluated at various levels: cellular, molecular, and integrated. The results at the cellular level indicate that MMCMs (M) show a better anti-proliferation activity than raw MTX and could induce… Expand
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Characterization and biological evaluation of paclitaxel-loaded poly(L-lactic acid) microparticles prepared by supercritical CO2.
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The in vitro and in vivo anti-tumor effect of layered double hydroxides nanoparticles as delivery for podophyllotoxin.
In vitro cytotoxicity experiment indicated that PPT-LDH nanoparticles show better anti-tumor efficacy than PPT and are more readily taken up by Hela cells, implying that LDH nanoparticle are the potential carrier of anti-Tumor drugs in a range of new therapeutic applications. Expand
Synergistic anti-tumor activity of paclitaxel-incorporated conjugated linoleic acid-coupled poloxamer thermosensitive hydrogel in vitro and in vivo.
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Study of Fe3O4–PLLA–PEG–PLLA magnetic microspheres based on supercritical CO2: Preparation, physicochemical characterization, and drug loading investigation
Abstract The Fe3O4–poly( l -lactide)–poly(ethylene glycol)–poly( l -lactide) magnetic microspheres (Fe3O4–PLLA–PEG–PLLA MMPs) were successfully developed in a process of suspension-enhancedExpand
Enhanced cytotoxicity and activation of ROS-dependent c-Jun NH2-terminal kinase and caspase-3 by low doses of tetrandrine-loaded nanoparticles in Lovo cells--a possible Trojan strategy against cancer.
  • Xiaolin Li, Donghui Zhen, +6 authors W. Sun
  • Chemistry, Medicine
  • European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2010
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In vitro cytot toxic tests showed that the DBMs were cytotoxic to HL60 and EMT‐6 cells, manifested as inhibition of cell proliferation and suppression in c‐myc expression, consistent with DOX, and the approach of coupling DOX to magnetosomes may have clinical potential in anti‐tumor drug delivery. Expand
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