The in vitro activity of moxalactam against 430 clinical, bacterial isolates.


The in vitro activity of the novel beta-lactam antibiotic moxalactam against 430 bacterial isolates was determined by an agar dilution method. Moxalactam was highly active against Enterobacteriaceae including indole-positive Proteus and Providencia, all isolates being susceptible to 1.0 microgram/ml or less. The drug was somewhat less active against Gram-positive cocci and Pseudomonas aeruginosa, and enterococci were highly resistant. All Haemophilus influenzae isolates were inhibited by 0.06 microgram/ml or less. Activity against Bacteroides fragilis was good but wide variations of minimal inhibitory concentrations were noted. Moxalactam may become a useful alternative to the aminoglycosides in the treatment of serious infections caused by Gram-negative bacteria.

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@article{Digranes1982TheIV, title={The in vitro activity of moxalactam against 430 clinical, bacterial isolates.}, author={Asbj\orn Digranes and E Benonisen and W L Dibb and B Ostervold}, journal={Acta pathologica, microbiologica, et immunologica Scandinavica. Section B, Microbiology}, year={1982}, volume={90 1}, pages={69-72} }