The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain

@article{Wal2016TheIV,
  title={The in vitro mechanisms and in vivo efficacy of intravenous lidocaine on the neuroinflammatory response in acute and chronic pain},
  author={S.E.I. van der Wal and S.A.S. van den Heuvel and Sandra A. Radema and B.F.M. Berkum and Michiel Vaneker and Monique A H Steegers and G J Scheffer and Kris C P Vissers},
  journal={European Journal of Pain},
  year={2016},
  volume={20}
}
The neuroinflammatory response plays a key role in several pain syndromes. Intravenous (iv) lidocaine is beneficial in acute and chronic pain. This review delineates the current literature concerning in vitro mechanisms and in vivo efficacy of iv lidocaine on the neuroinflammatory response in acute and chronic pain. 

Pharmacology in the management of chronic pain

The Efficacy of Systemic Lidocaine in the Management of Chronic Pain: A Literature Review

Intravenous lidOCaine and lidocaine patch are effective and safe for the treatment of several chronic or neuropathic pain syndromes and the use of lidocane during surgery could prevent the development of some chronic post-surgical pain syndroma.

Intravenous lidocaine in the management of chronic peripheral neuropathic pain: a randomized-controlled trial

It is found that there is no significant long-term analgesic or quality of life benefit from IV lidocaine relative to control infusion for chronic peripheral neuropathic pain.

A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and in the multidisciplinary care of chronic pain in the pediatric population.

Intravenous infusion of lidocaine enhances the efficacy of conventional treatment of postherpetic neuralgia

Daily intravenous lidocaine (4 mg/kg for 5 days) enhanced the outcome of PHN treatment, reduced the amount of analgesic medicine and shortened the length of hospital stay with no obvious adverse side effects.

Chapter 5 A Review of Intravenous Lidocaine Infusion Therapy for Paediatric Acute and Chronic Pain Management

Large multi-centre randomised controlled trials are required to provide the evidence-base to confirm that IVLT is indeed an effective and safe treatment option in acute preventative multimodal analgesia and in the multidisciplinary care of chronic pain in the pediatric population.

Intravenous Lidocaine: Old-School Drug, New Purpose—Reduction of Intractable Pain in Patients with Chemotherapy Induced Peripheral Neuropathy

Iv lidocaine has direct analgesic effect in CIPN with a moderate long-term effect and seems to influence the area of cold and pinprick perception.

Perioperative lidocaine infusions for the prevention of chronic postsurgical pain: a systematic review and meta-analysis of efficacy and safety

Current limited clinical trial data and biological plausibility support lidocaine infusions use to reduce the development of CPSP without full assurances as to its safety, but this hypothesis should be addressed in future definitive clinical trials with comprehensive safety assessment and reporting.

The role of lidocaine in perioperative pain and recovery management

The use of intravenous lidocaine in the perioperative period is mainly associated with better pain control, reduced opioid use, diminished incidence of postoperative nausea, vomiting, and ileus, and exhibits antithrombotic effects.

The analgesic efficacy and duration of lidocaine on vascular pain induced by hypertonic saline infusion: a double-blinded, randomized control trial

A single bolus of Lidocaine was effective in eliminating the pain induced by hypertonic saline infusion, but just for a short period of time, and only provides a short analgesic duration for local vein.
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References

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It is demonstrated that intravenous lidocaine affects pain in response to cool stimuli more than mechanical pain in subjects with neuropathic pain.

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Intravenous lidocaine administration titrated to 5 mg/L demonstrated a significant decrease in mechanical and thermal allodynia for three months, lessened associated inflammatory components of CRPS, and only minimal side effects and no severe complications.

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