The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.

@article{Rondon2010TheIO,
  title={The improvement of the anti-hyperalgesic effect of ketamine and of its isomers by the administration of ifenprodil.},
  author={Eric Schmidt Rondon and Andr{\'e} Schwambach Vieira and Carlos Augusto Ara{\'u}jo Valad{\~a}o and Carlos Am{\'i}lcar Parada},
  journal={European journal of pharmacology},
  year={2010},
  volume={647 1-3},
  pages={
          84-9
        }
}
Intrathecal or epidural administration of NMDA (N-methyl-D-aspartate) receptors antagonists, in special ketamine and ifenprodil are used to control moderate to severe hyperalgesia in humans. Activation of NMDA receptor usually requires binding of two agonists, glutamate and glycine, in different receptor subunits. Ketamine is a NMDA receptor antagonist and acts at phencyclidine site in NR1 subunit while ifenprodil is a selective NR2B subunit antagonist of NMDA receptor. The aim of this study… CONTINUE READING