The importance of timing in melatonin administration in a blind man

@article{Tzischinsky1992TheIO,
  title={The importance of timing in melatonin administration in a blind man},
  author={Orna Tzischinsky and Itzhak Pal and Rachel Epstein and Yaron Dagan and Peretz Lavie},
  journal={Journal of Pineal Research},
  year={1992},
  volume={12}
}
Abstract: An 18‐year‐old blind man suffered from chronic sleep disturbances associated with daytime fatigue and excessive daytime somnolence. After two unsuccessful treatment regimens with 5 mg and 10 mg melatonin administered at bedtime (2200–2230), a third regimen of 5 mg melatonin administered at 2000 for 3 weeks resulted in a successful resolution of his sleep disturbances. We suggest that the efficacy of melatonin in ameliorating sleep disturbances because of alterations in circadian… 
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References

SHOWING 1-10 OF 12 REFERENCES
Correction of non–24‐hour sleep/wake cycle by melatonin in a blind retarded boy
TLDR
Melatonin convincingly entrained the endogenous rhythm to the appropriate chronological 24‐hour day in this 9‐year‐old, blind boy with severe mental retardation with a chronic sleep/wake disturbance.
Circadian rhythms in 6-sulphatoxymelatonin and nocturnal sleep in blind children.
TLDR
Delayed secretory peaks in aMT6s were significantly associated with disturbed nocturnal sleep and with complaints about morning fatigue in totally blind children.
Melatonin Administration to Blind People: Phase Advances and Entrainment
TLDR
The purpose of this study was to test the phase-shifting and entraining effects of melatonin in human subjects, and found five totally blind men found to have free-running endogenous melatonin rhythms to be remarkably stable.
Influence of Melatonin Treatment on Human Circadian Rhythmicity before and after a Simulated 9-Hr Time Shift
TLDR
Melatonin treatment can accelerate resynchronization of the melatonin excretion rhythm after eastward time zone transitions, but the improvement is not, however, sufficiently great that it can be recommend melatonin for the alleviation of jet lag.
Some effects of jet-lag and their alleviation by melatonin
TLDR
Melatonin significantly improved ‘jet lag’ in healthy volunteers flown from London to San Francisco between 20 November 1985 and 25 January 1986 and remained there for 14 days prior to flight home.
Bioavailability of oral melatonin in humans.
TLDR
The area under the concentration-time curve for serum melatonin correlated well with the cumulative melatonin excretion during the initial 15 h after melatonin's administration, indicating that either approach can be used to estimate the absorption of orally administered melatonin.
Effects of bilateral adrenalectomy on the induction of learned helplessness behavior.
TLDR
It is concluded that secretion from the adrenal cortex is necessary for the incorporation of a learned response after stress and that a dysregulation of the hypothalamic-pituitary-adrenal axis seems to be involved in helpless behavior.
Entrainment of a previously free - running blind human with melatonin administration
  • Sleep Res .
  • 1990
...
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