The importance of the putative helices 4 and 5 of human vitamin D(3) receptor for conformation and ligand binding.

Abstract

The 3-D structure of the human vitamin D(3) receptor has not been solved to date. To study the conformation of the ligand binding pocket and the amino acid residues important for binding of calcitriol and its synthetic 20-epi analog MC1288, we have introduced several point mutations into putative helices 4 and 5 of human vitamin D(3) receptor by site… (More)

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