The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.

@article{MuozGarcia2014TheIO,
  title={The importance of the lipoxygenase-hepoxilin pathway in the mammalian epidermal barrier.},
  author={Agust{\'i} Mu{\~n}oz-Garcia and Christopher P Thomas and Diane S Keeney and Yuxiang Zheng and Alan R. Brash},
  journal={Biochimica et biophysica acta},
  year={2014},
  volume={1841 3},
  pages={401-8}
}
This review covers the background to discovery of the two key lipoxygenases (LOX) involved in epidermal barrier function, 12R-LOX and eLOX3, and our current views on their functioning. In the outer epidermis, their consecutive actions oxidize linoleic acid esterified in ω-hydroxy-ceramide to a hepoxilin-related derivative. The relevant background to hepoxilin and trioxilin biochemistry is briefly reviewed. We outline the evidence that linoleate in the ceramide is the natural substrate of the… CONTINUE READING

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