The importance of the hypothalamo-pituitary-adrenal axis as a therapeutic target in anorexia nervosa

@article{Khalil2017TheIO,
  title={The importance of the hypothalamo-pituitary-adrenal axis as a therapeutic target in anorexia nervosa},
  author={Rami Bou Khalil and Lama Souaiby and Nassim Fares},
  journal={Physiology \& Behavior},
  year={2017},
  volume={171},
  pages={13-20}
}
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The aim of the present review is to provide an updated overview of the many endocrine changes in anorexia nervosa in a clinical perspective by identifying biomarkers associated with different stages of weight loss and re-nutrition combined with psychometric data.
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Animal models that integrate either spontaneous genetic mutations or experimentally-induced food restriction with hyperactivity and/or social stress recapitulate the main metabolic and endocrine alterations of AN and provide mechanistic information between undernutrition state and symptoms of the disease.
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Content regarding eating disorder diagnoses but also descriptions of disordered eating behavior in general are reviewed, which has been described and discussed in German psychiatric textbooks throughout the past 200 years.
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Fear and disgust are negative emotions that seem to be clinically associated which better explains the comorbidity of ED with PD.
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