The importance of the effect of shear stress on endothelial cells in determining the performance of hemoglobin based oxygen carriers.

Abstract

The lack of blood donations and the threat of infections from blood and blood products have led to extensive research into the development of blood substitutes. The latest generation of hemoglobin based oxygen carriers (HBOC) has been shown to induce side effects like hypertension, vasoconstriction, inflammation and oxidative stress. HBOC are able to… (More)
DOI: 10.1016/j.biomaterials.2008.09.051

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