The importance of the carboxyl-terminal domain of cardiac troponin C in Ca2+-sensitive muscle regulation.

@article{Calvert2000TheIO,
  title={The importance of the carboxyl-terminal domain of cardiac troponin C in Ca2+-sensitive muscle regulation.},
  author={Melanie Calvert and Douglas G. Ward and Hylary R. Trayer and Ian P. Trayer},
  journal={The Journal of biological chemistry},
  year={2000},
  volume={275 42},
  pages={32508-15}
}
The interactions between troponin I and troponin C are central to the Ca(2+)-regulated control of striated muscle. Using isothermal titration microcalorimetry we have studied the binding of human cardiac troponin C (cTnC) and its isolated domains to human cardiac troponin I (cTnI). We provide the first binding data for these proteins while they are free in solution and unmodified by reporter groups. Our data reveal that the C-terminal domain of cTnC is responsible for most of the free energy… CONTINUE READING

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