The importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome.

@article{Knudsen2001TheIO,
  title={The importance of structural transitions of the switch II region for the functions of elongation factor Tu on the ribosome.},
  author={Charlotte Rohde Knudsen and Hans-Joachim Wieden and Marina V. Rodnina},
  journal={The Journal of biological chemistry},
  year={2001},
  volume={276 25},
  pages={22183-90}
}
Elongation factor Tu (EF-Tu) undergoes a large conformational transition when switching from the GTP to GDP forms. Structural changes in the switch I and II regions in the G domain are particularly important for this rearrangement. In the switch II region, helix alpha2 is flanked by two glycine residues: Gly(83) in the consensus element DXXG at the N terminus and Gly(94) at the C terminus. The role of helix alpha2 was studied by pre-steady-state kinetic experiments using Escherichia coli EF-Tu… CONTINUE READING
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Switch II Region of EF-Tu on the Ribosome

  • M. A. Geeves, K. C. Holmes
  • Annu. Rev. Biochem
  • 1999

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