The importance of pharmacological synergy in psychoactive herbal medicines.

  title={The importance of pharmacological synergy in psychoactive herbal medicines.},
  author={Marcello Spinella},
  journal={Alternative medicine review : a journal of clinical therapeutic},
  volume={7 2},
The therapeutic effects of many herbal medicines have been well established; however, definitive mechanisms of action remain to be elucidated for many psychoactive herbal medications. Although several mechanisms have been identified, they are often insufficient to account for the observed effects of the plant or its extracts. This review emphasizes that, in addition to searching for more potent mechanisms, one must consider the additive and supra-additive effects of a plant's multiple… CONTINUE READING
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Publications referenced by this paper.
Showing 1-10 of 55 references

John’s wort for depression: a meta-analysis of welldefined clinical trials

HL Kim, J Streltzer, D St.Goebert
J Nerv Ment Dis 1999;187:532-538 • 1999

Antidepressant activity of Hypericum perforatum and hyperforin : the neglected possibility

SS Chatterjee, M Noldner, E Koch, C Erdelmeier
Pharmacopsychiatry • 1998