The importance of neuritic plaques and tangles to the development and evolution of AD

@article{Tiraboschi2004TheIO,
  title={The importance of neuritic plaques and tangles to the development and evolution of AD},
  author={Pietro Tiraboschi and Lawrence A. Hansen and Leon Thal and Jody Corey-Bloom},
  journal={Neurology},
  year={2004},
  volume={62},
  pages={1984 - 1989}
}
Objective: To determine the relation of neuritic plaques (NPs) and neurofibrillary tangles (NFTs) to the development and evolution of Alzheimer disease (AD). Methods: An autopsy series of 102 patients with dementia and pathologically confirmed AD and 29 normal control subjects (NCs) was studied. AD cases were stratified according to their last Mini-Mental State Examination (MMSE) before death as mild, moderate, severe, or very severe. NPs and NFTs were enumerated in the midfrontal (MF… Expand
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