The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma

@inproceedings{Barbai2015TheIO,
  title={The importance of microenvironment: the role of CCL8 in metastasis formation of melanoma},
  author={Tam{\'a}s Barbai and Zsuzsanna Fejős and L{\'a}szl{\'o} G. Pusk{\'a}s and J{\'o}zsef T{\'i}m{\'a}r and E. F. Gandolfo Raso},
  booktitle={Oncotarget},
  year={2015}
}
We have attempted to characterize the changes occurring on the host side during the progression of human melanoma. To investigate the role of tumor microenvironment, we set up such an animal model, which was able to isolate the host related factors playing central role in metastasis formation. One of these 'factors', CCL12, was consequently selected and its behavior was examined alongside its human homologue (CCL8). In our animal model, metastasis forming primary melanoma in the host exhibited… CONTINUE READING

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