The importance of lytic and nonlytic immune responses in viral infections.

  title={The importance of lytic and nonlytic immune responses in viral infections.},
  author={Dominik Wodarz and Jan Pravsgaard Christensen and Allan Randrup Thomsen},
  journal={Trends in immunology},
  volume={23 4},
Antiviral immune effector mechanisms can be divided broadly into lytic and nonlytic components. We use mathematical models to investigate the fundamental question of which type of response is required to combat different types of viral infection. According to our model, the relative roles of the two types of component depend on the cytopathicity of the virus relative to its rate of replication. If the viral cytopathicity is low relative to the rate of viral replication, the model predicts that… CONTINUE READING


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Publications referenced by this paper.
Showing 1-6 of 6 references

Role of the B - cell response in recovery of mice from primary influenza virus infection

D. Moskophidis, D. Kioussis
Immunol . Rev . • 1997

Molecular mechanisms of lymphocytemediated cytotoxicity and their role in immunological protection and pathogenesis in vivo

D. Kagi, H. Hengartner
Annu . Rev . Immunol . • 1996

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