The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations?

@article{Pinholt2011TheIO,
  title={The importance of interfaces in protein drug delivery - why is protein adsorption of interest in pharmaceutical formulations?},
  author={Charlotte Pinholt and Rune Andersen Hartvig and Natalie J. Medlicott and Len{\'e} Ilyna Jorgensen},
  journal={Expert opinion on drug delivery},
  year={2011},
  volume={8 7},
  pages={
          949-64
        }
}

• Charlotte Pinholt, Rune Andersen Hartvig, +1 author Lené Ilyna Jorgensen
• Published 2011 in Expert opinion on drug delivery
• DOI:10.1517/17425247.2011.577062

INTRODUCTION In the area of peptide and protein drug products, interfaces are present as part of the basic liquid formulation, when freeze-dried formulations are reconstituted and when particulate delivery systems are prepared. Proteins are known to interact with these interfaces, and the effects seen are often irreversible adsorption and structural changes. AREAS COVERED This review focuses on the ways in which peptides and proteins interact with surfaces and interfaces, and the effect these… CONTINUE READING

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