The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.

@article{Bhm2007TheIO,
  title={The importance of endothelin-1 for vascular dysfunction in cardiovascular disease.},
  author={Felix B{\"o}hm and John Pernow},
  journal={Cardiovascular research},
  year={2007},
  volume={76 1},
  pages={
          8-18
        }
}
Endothelin (ET)-1 is a potent vasoconstrictor peptide originally isolated from endothelial cells. Its production is stimulated in a variety of different cell types under the influence of risk factors for cardiovascular disease and during the development of cardiovascular disease. Based on these observations and the biological effects induced by ET-1, including profound vasoconstriction, pro-inflammatory actions, mitogenic and proliferative effects, stimulation of free radical formation and… Expand
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