The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis.

@article{Daly2005TheIO,
  title={The importance of colonic butyrate transport to the regulation of genes associated with colonic tissue homoeostasis.},
  author={Kristian Daly and Mark A Cuff and Fen Kevin Fung and Soraya P. Shirazi-Beechey},
  journal={Biochemical Society transactions},
  year={2005},
  volume={33 Pt 4},
  pages={
          733-5
        }
}
The transition from normality to malignancy in colorectal cancer is characterized by alterations in the expression of genes associated with the maintenance of tissue homoeostasis. Butyrate, a product of microbial fermentation of dietary fibre in the colon, is known to regulate a number of genes associated with the processes of proliferation, differentiation and apoptosis of colonic epithelial cells, and, hence, homoeostasis of colonic tissue. We have shown previously that the transport of… CONTINUE READING

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