The importance of clinical research: the role of thermogenesis in human obesity.

@article{Schoeller2001TheIO,
  title={The importance of clinical research: the role of thermogenesis in human obesity.},
  author={Dale A. Schoeller},
  journal={The American journal of clinical nutrition},
  year={2001},
  volume={73 3},
  pages={511-6}
}
The hypothesis that human obesity is caused by deficient thermogenesis has been proposed by many investigators throughout the 20th century. Supporting evidence was obtained from epidemiologic studies of dietary intake, animal models with aberrant brown adipose tissue (BAT) function, and genetic studies of human polymorphisms of genes involved in BAT function. Supporting evidence was also obtained from clinical studies of the thermogenic effect of meals, but these measures capture only a short… CONTINUE READING

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