The importance of an isolated central nervous system relapse in children with acute lymphoblastic leukemia.

@article{George1985TheIO,
  title={The importance of an isolated central nervous system relapse in children with acute lymphoblastic leukemia.},
  author={Stephen L. George and Judith J Ochs and Alvin M. Mauer and Joseph V. Simone},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={1985},
  volume={3 6},
  pages={776-81}
}
We assessed the influence of an initial isolated meningeal relapse on treatment outcome in 839 children with acute lymphoblastic leukemia (ALL) who were admitted to St Jude Children's Research Hospital (Memphis) from mid-1967 through mid-1979. The patients were entered in a series of five clinical trials (Total Therapy Studies V through IX), each designed to test one or more modifications of treatment for ALL. Two groups were compared: 699 children who received CNS prophylaxis (2,400-rad… CONTINUE READING

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