The importance of Na+/H+ exchanger for the generation of procoagulant activity by porcine blood platelets.


This study addresses the role of the Na+/H+ exchanger (NHE) in the generation of procoagulant activity in blood platelets. It was found that monensin (simulating the action of NHE) and gramicidin (causing sodium influx without concomitant H+ efflux) produced a dose- and time-dependent increase in platelet procoagulant activity. Alkalinization of platelet… (More)


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