The importance of CD25+ CD4+ regulatory T cells in mouse hepatic allograft tolerance.

@article{Jiang2006TheIO,
  title={The importance of CD25+ CD4+ regulatory T cells in mouse hepatic allograft tolerance.},
  author={Xiaofeng Jiang and Miwa Morita and Atsushi Sugioka and Michishige Harada and Satoshi Kojo and Hiroshi Wakao and Hiroshi Watarai and Nobuhiro Ohkohchi and Masaru Taniguchi and Ken-ichiro Seino},
  journal={Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society},
  year={2006},
  volume={12 7},
  pages={1112-8}
}
In mouse liver transplantation, tolerance is readily inducible. Recent studies have revealed that CD25+ CD4+ regulatory T cells play an important role in regulating various immune responses, including transplant tolerance. However, the contribution of these cells to tolerance in mouse liver transplantation has not been elucidated. We showed here that depletion of CD25+ CD4+ T cells increased proliferative response of CD4+ T cells and cytotoxic T lymphocyte induction of CD8+ T cells. Depletion… CONTINUE READING

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