The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain.

@article{Tammineni2013TheIO,
  title={The import of the transcription factor STAT3 into mitochondria depends on GRIM-19, a component of the electron transport chain.},
  author={Prasad Tammineni and Chandrashekhar Anugula and Fareed Mohammed and Murari Anjaneyulu and Andrew C Larner and Naresh Babu Venkata Sepuri},
  journal={The Journal of biological chemistry},
  year={2013},
  volume={288 7},
  pages={4723-32}
}
The signal transducer and activator of transcription 3 (STAT3), a nuclear transcription factor, is also present in mitochondria and regulates cellular respiration in a transcriptional-independent manner. The mechanism of STAT3 import into mitochondria remains obscure. In this report we show that mitochondrial-localized STAT3 resides in the inner mitochondrial membrane. In vitro import studies show that the gene associated with retinoid interferon induced cell mortality 19 (GRIM-19), a complex I… CONTINUE READING
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