The implications of the shared genetics of psychiatric disorders

  title={The implications of the shared genetics of psychiatric disorders},
  author={Michael C O'Donovan and Michael J. Owen},
  journal={Nature Medicine},
Recent genomic studies have revealed the highly polygenic nature of psychiatric disorders, including schizophrenia, bipolar disorder and major depressive disorder. Many of the individual genetic associations are shared across multiple disorders in a way that points to extensive biological pleiotropy and further challenges the biological validity of existing diagnostic approaches. Here we argue that the existence of risk alleles specific to a single diagnostic category is unlikely. We also… CONTINUE READING
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Analysis of intellectual disability copy number variants for association with schizophrenia

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large-scale proof of concept

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