The implications of CFTR structural studies for cystic fibrosis drug development.

Abstract

Development of Cystic Fibrosis Transmembrane conductance Regulator (CFTR) modulators, targeting the root cause of cystic fibrosis (CF), represents a challenge in the era of personalized medicine, as CFTR mutations lead to a variety of phenotypes, which likely require different, specific treatments. CF drug development is also complicated by the need to… (More)
DOI: 10.1016/j.coph.2017.09.006

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Cite this paper

@article{Callebaut2017TheIO, title={The implications of CFTR structural studies for cystic fibrosis drug development.}, author={Isabelle Callebaut and Brice Hoffmann and J Mornon}, journal={Current opinion in pharmacology}, year={2017}, volume={34}, pages={112-118} }