The implication of osteopontin (OPN) expression and genetic polymorphisms of OPN promoter in oral carcinogenesis.

Abstract

Osteopontin (OPN) is an extracellular matrix protein in hard tissues. The polymorphism in promoter region of OPN gene correlates to different gene expression and might implicate potential roles in tumor progression and metastasis. Immunohistochemistry (IHC) was utilized to detect the OPN expression in 58 oral squamous cell carcinoma (OSCC) tissues and… (More)
DOI: 10.1016/j.oraloncology.2010.01.018

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