The impairing effects of chaetochromin D on mitochondrial respiration and structure

  title={The impairing effects of chaetochromin D on mitochondrial respiration and structure},
  author={Satoru Mori and K Kawai and Yoshinori Nozawa and Kiyotaka Koyama and Shinsaku Natori},
  journal={Mycotoxin Research},
Chaetochromin D, a toxic secondary metabolite ofChaetomlum graclle, was examined for impairing effects on mitochondrial respiration and structure (swelling-induction) using isolated rat liver mitochondria to gain Insight into the molecular mechanism for Its cytotoxicity. Chaetochromin D exerted similar mode of effects to those of chaetochromin A, cephalochromin, and ustilaginoldin A on mitochondrial reactions, causing uncoupling of oxidative phosphorylation, depression of state 3 respiration… 

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