The impairing effects of chaetochromin D on mitochondrial respiration and structure

@article{Mori2010TheIE,
  title={The impairing effects of chaetochromin D on mitochondrial respiration and structure},
  author={Satoru Mori and K Kawai and Yoshinori Nozawa and Kiyotaka Koyama and Shinsaku Natori},
  journal={Mycotoxin Research},
  year={2010},
  volume={9},
  pages={85-93}
}
Chaetochromin D, a toxic secondary metabolite ofChaetomlum graclle, was examined for impairing effects on mitochondrial respiration and structure (swelling-induction) using isolated rat liver mitochondria to gain Insight into the molecular mechanism for Its cytotoxicity. Chaetochromin D exerted similar mode of effects to those of chaetochromin A, cephalochromin, and ustilaginoldin A on mitochondrial reactions, causing uncoupling of oxidative phosphorylation, depression of state 3 respiration… Expand
5 Citations
The respiration-impairing effect of rubroskyrin, a toxic metabolite
TLDR
Spectroscopic study at various pHs revealed that rubroskyrin possessed a pK value within the range of physiological pH, suggesting that ruboskyr in is a weak acid-type uncoupler capable of conducting protons across mitochondrial inner membrane. Expand
Reexamination of respiration-impairing effect of bikaverin on isolated mitochondria
TLDR
It was concluded that bikaverin showed no uncoupling effect (no decrease in P/O ratio) at low concentrations and did it at high concentrations in consequence of disturbing the ion permeability in the mitochondrial inner membranes. Expand
The interaction of rubroskyrin, a modified bis-anthraquinone pigment fromPenicillium islandicum Sopp, with respiratory chain of liver mitochondria
TLDR
Rubroskyrin showed a redox interaction with the NAD-linked respiratory chain of SMP, promoting NADH oxidase in the presence of roten one, a specific inhibitor to coupling site I of the respiratory chain, indicating a generation of an electron transport shunt from a rotenone-insensitive site of NADH dehydrogenase to dissolved oxygen. Expand
Bioactive bis-naphtho-γ-pyrones from rice false Smut pathogen Ustilaginoidea virens.
TLDR
The structures of the new compounds were elucidated by using (1D, 2D) NMR, high-resolution mass spectrometry, UV, and circular dichroism, as well as by comparison with the literature data, and a plausible biosynthesis pathway was proposed. Expand
Bis-naphtho-γ-pyrones from Fungi and Their Bioactivities
TLDR
This mini-review aims to briefly summarize bis-naphtho-γ-pyrones occurrence, biosynthesis, and structure, as well as their biological activities. Expand

References

SHOWING 1-10 OF 20 REFERENCES
Toxicity of emestrin, a new macrocyclic dithiodioxopiperazine mycotoxin, to mitochondrial function
The effect of emestrin, a new macrocyclic epidithiodioxopiperazine mycotoxin from severalEmericella species, on mitochondrial reactions was studied using isolated rat liver mitochondria to gainExpand
The effect of pyrrolnitrin on mitochondrial reactions: the induction of swelling.
An antifungal antibiotic, pyrrolnitrin, was found to show very similar biological activities to those of imidazole antimycotics on isolated mitochondria. Pyrrolnitrin caused drastic swelling ofExpand
The uncoupling effect of flavoglaucin, a quinol pigment from Aspergillus chevalieri (Mangin), on mitochondrial respiration.
TLDR
Flavoglaucin exhibited a strong uncoupling effect on oxidative phosphorylation, enhanced the latent ATPase activity, and elicited a drastic swelling of mitochondria that led to the exhaustion of ATP in cells, which may be responsible for its cytotoxicity. Expand
Biochemical studies on peptide alkaloids: Induction of ion selective mitochondrial swelling
The effect of frangulanine, a cyclopeptide alkaloid isolated fromHovenia dulcis Thunb., on mitochondrial swelling was studied. Frangulanine induced mitochondrial swelling in 0.15 M KCl solution atExpand
Averufin, an anthraquinone mycotoxin possessing a potent uncoupling effect on mitochondrial respiration
Averufin and averufin dimethylether from Aspergillus versicolor were examined for their uncoupling effects on oxidative phosphorylation in isolated rat liver mitochondria to get insight into the modeExpand
Chlorination-induced enhancement of biological activities in imidazole antimycotics. A possible explanation to the molecular mechanism for their antimycotic activities.
TLDR
The effect of imidazole antimycotics on mitochondrial functions were compared by the experiment with isolated rat liver mitochondria and it was found that their potencies in the uncoupling effect on oxidative phosphorylation, in the stimulation of latent ATPase activity, and in the induction of swelling in mitochondria were enhanced by the increased chlorination of the molecule. Expand
Cytotoxicity and antitumor activities of fungal bis(naphtho-gamma-pyrone) derivatives.
TLDR
It was suggested that other still unknown mechanism(s) might induce cytotoxic lesion, resulting in the inhibition of the macromolecule syntheses. Expand
MYOCARDIAL AND HEPATIC NECROSIS AND BONE MARROW SUPPRESSION IN MICE INDUCED BY SINGLE ADMINISTRATION OF CHAETOCHROMIN, A POLYPHENOLIC MYCOTOXIN PRODUCED BY CHAETOMIUM spp
A sublethal dose of 140mg/kg b.w. of chaetochromin, a mycotoxin produced by Chaetomium spp, caused lesions in various organs characterized by rather slow-developing necrosis and repair in the ICRExpand
A new anti-mycotic drug tioxaprofen and its uncoupling effect on isolated mitochondria
An oxazole compound, tioxaprofen, exerted a strong anti-mycotic activity againstTrichophyton mentagrophytes andT. rubrum, which were major dermatophytes from patients. It was found that tioxaprofenExpand
The osmotic behavior and permeability to non-electrolytes of mitochondria.
Abstract The volume changes of rat liver mitochondria exposed to hypotonic solutions or to solutions of penetrating non-electrolytes were studied by direct estimation of mitochondrial volume fromExpand
...
1
2
...