The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection

@article{Gabrieli1988TheIL,
  title={The impaired learning of semantic knowledge following bilateral medial temporal-lobe resection},
  author={John D. E. Gabrieli and Neal J. Cohen and Suzanne Corkin},
  journal={Brain and Cognition},
  year={1988},
  volume={7},
  pages={157-177}
}
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268 Citations
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268 Citations

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Evidence for semantic learning in profound amnesia: An investigation with patient H.M.
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Although H.M.M.'s semantic learning was clearly impaired, the results provide robust, unambiguous evidence that some new semantic learning can be supported by structures beyond the hippocampus proper.
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A densely amnesic man is described who has acquired explicit semantic knowledge of famous names and vocabulary words that entered popular culture after the onset of his amnesia and who possessed virtually no explicit knowledge of the meaning of these words or the identities of these individuals.
Does the Medial Temporal Lobe Bind Phonological Memories?
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This work reexamined phonological memory in the amnesic patient HM and interpret the data in terms of a model of lexical representation where temporal lobe damage disrupts the processes that normally bind semantic and phonological representations.
Knowledge of New English vocabulary in amnesia: an examination of premorbidly acquired semantic memory.
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Findings suggest a deficit in the controlled search and retrieval of semantic information in Korsakoff patients, which could be explained by explanations of temporally graded retrograde amnesia.
Acquisition of post-morbid vocabulary and semantic facts in the absence of episodic memory.
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The case of R.S., a 49-year-old amnesic man, is reported, who is found to have acquired information about famous people, public events and new vocabulary during the 13-year period since he becameAmnesic, despite having no measurable anterograde episodic memory function and a profound loss of autobiographical memory.
Bilateral medial temporal lobe damage does not affect lexical or grammatical processing: Evidence from amnesic patient H.M.
TLDR
It is concluded that medial temporal lobe structures are not critical for retention and use of already acquired lexical information or for grammatical processing, but they are required for acquisition ofLexical information, as evidenced in previous studies revealing H.M.'s profound impairment at learning new words.
The medial temporal-lobe amnesic syndrome.
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  • Psychology, Biology
    The Psychiatric clinics of North America
  • 2005
Failure to acquire new semantic knowledge in patients with large medial temporal lobe lesions
TLDR
The results demonstrate that the capacity for new semantic learning can be absent, or nearly absent, when there is virtually complete damage to the MTL bilaterally, and raise the possibility that the acquisition of conscious (declarative) knowledge about the world cannot be supported by structures outside the M TL, even with extended exposure.
Preserved Semantic Learning in an Amnesic Patient
Medial Temporal Lobe Amnesia: Gradual Acquisition of Factual Information by Nondeclarative Memory
Most amnesic patients with damage to the medial temporal lobe retain some capacity to learn new information about facts and events. In many cases, the learning appears to depend on a residual ability…
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References

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