The impacts of errors in individual genotyping and DNA pooling on association studies.

@article{Zou2004TheIO,
  title={The impacts of errors in individual genotyping and DNA pooling on association studies.},
  author={Guohua Zou and Hongyu Zhao},
  journal={Genetic epidemiology},
  year={2004},
  volume={26 1},
  pages={
          1-10
        }
}
Case-control association studies using unrelated individuals may offer an effective approach for identifying genetic variants that have small to moderate disease risks. In general, two different strategies may be employed to establish associations between genotypes and phenotypes: (1) collecting individual genotypes or (2) quantifying allele frequencies in DNA pools. These two technologies have their respective advantages. Individual genotyping gathers more information, whereas DNA pooling may… CONTINUE READING

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